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Alzheimer's Disease 

Statistics on Alzheimer’s Disease:

More than 5 million Americans are living with Alzheimer’s. By 2050 this number could be as high as 16 million.

Every 66 Seconds someone in the United States develops the disease.

1 in 3 seniors dies with Alzheimer’s or another dementia. It is the 6th leading cause of death in the United States. It kills more than breast and prostate cancer combined.
(Source: Alzheimer’s Association, www.alz.org/facts)

US Patent 8673368, Mar 18, 2014 - Cannabinoid-containing plant extracts as neuroprotective agents

US Patent Filing US 6,630,507 B1 Cannabinoids as Antioxidants and Neuroprotectants

How Cannabinoids May Slow Brain Aging 

Szalavitz, Maia

Time. 2012 Oct 29, (Full News article).

Cannabinoid Modulation of Neuroinflammatory Disorders

Saito, Viviane M., et al.

Current Neuropharmacology. 2012 Jun, 10(2): 159-166 (Full).

Terpenoids as Potential Anti-Alzheimer’s Disease Therapeutics

Yoo, Ki-Yeol, et al.

Molecules. 2012 Mar 12, 17(3): 3524-3528 (Full).  

An Introduction to the Medical Benefits of Cannabis

Acton, Jeremy, et al.

NORML. 2011 Apr 4 (Full).  

Alzheimer’s disease; taking the edge off with cannabinoids?

Campbell, VA, et al.

British Journal of Pharmacology. 2009 Jan 29, 152(5): 655-662 (Full).

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

Zuardi, Antonio Waldo

Revista Brasileira de Psiquiatria. 2008 Sep, 30(3) (Full). 

A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Patholiogy

Eubanks, Lisa M., et al.

Molecular pharmaceutics. 2006, 3(6): 773-777 (Full).

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

Ehrhart, Jared, et al.

Journal of Neuroinflammation. 2005 Dec 12, 2(29) (Full).

Prevention of Alzheimer’s Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation

Ramirez, Belen G, et al.

The Journal of Neuroscience. 2005 Feb 23, 25(8): 1904-1913 (Full). 

Neuroprotective effect of cannabidiol, a non-psychoactive component from cannabis sativa, on β-amyloid-induced toxicity in PC12 cells

Iuvone, Teresa, et al.

Journal of Neurochemistry. 2004 Apr, 89(1): 134-141 (Full).

Cannabinoids ablate release of TNFα in rat microglial cells stimulated with lypopolysaccharide 

Facchinetti, Fabrizio, et al.

GLIA. 2003 Jan 15, 41(2): 161-168 (Full).

The therapeutic potential of the endocannabinoid system for Alzheimer’s disease

Karl, Tim, et al.

Expert Opinion on Therapeutic Targets. 2012 Apr, (abstract).

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease   

Martin-Moreno, Ana Maria, et al.

Molecular Pharmacology. 2011 Feb 24, (abstract).

Cannabinoid Receptors and Endocannabinoids: Role in Neuroinflammatory and Neurodegenerative Disorders

Bisogno, Tiziana, et al.

CNS and Neurological Disorders: Drug Targets. 2010 Nov, 9(5): 564-573 (abstract). 


Cannabinoid System in Neurodegeneration: New Perspectives in Alzheimer’s Disease

Campillo, N.E., et al.

Mini Reviews in Medicinal Chemistry. 2009 May, (abstract).

The Role of the Endocannabinoid System in Alzheimer’s Disease: Facts and Hypothesis

Bosogno, Tiziana, et al.

Current Pharmaceutical Design. 2008 Aug, (abstract).

Cannabinoid CB2 receptor: a new target for controlling neural cell survival?

Fernandez-Ruiz, Javier, et al.

Trends in Pharmacological Sciences. 2007 Jan, (abstract).

A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Pathology

Eubanks, Lisa M, et al.

Molecular Pharmaceutics. 2006 Aug 9, 3(6): 773-777 (abstract).

Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in  β-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kB involvement

Esposito, Giuseppe, et al.

Neuroscience Letters. 2006 May 15, 399(1-2): 91-95 (abstract).

The marijuana component cannabidiol inhibits β-amyloid-induced tau protein hyperphosphorylation through Wnt/β-catenin pathway rescue in PC12 cells

Esposito, Giuseppe, et al.

Journal of Molecular Medicine. 2006 Mar, (abstract). 

The therapeutic potential of cannabis

Baker, David, et al.

The Lancet Neurology. 2003 May, (abstract).

Amnesia induced by β-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade

Mazzola, Carmen, et al.

European Journal of Pharmacology. 2003 Sep 23, (abstract).