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The Endocannabinoid System (ECS) Research

The Endocannabinoid System is an excitingly fascinating frontier for medicine and science. First discovered in the early 1990s, research into these complex system of receptors which you, everyone you know, and nearly all living animals possess has led to shockingly amazing findings - a large part of which explains why cannabinoid compounds from the cannabis plant are so effective at treating a multitude of diseases. Did you know that your body, at this very moment is producing compounds very similar to the ones found in marijuana? Future research into this field could very well evolve and advance medicine for the next several hundred years. It is important for doctors, scientists, researches, medical patients, and even the general public to learn more about this system which plays a huge role in each and everyone of our health.

We have provided a miniature library of some of the extensive research behind the ECS bellow! 

hyperlink to scholar search of the ECS - 42K+ results

Cannabinoids for Pain and Headaches: Primer 

Kim, Philip S, et al.

Current Pain and Headache Reports. 2017 Mar 9, 21:19 (abstract).

Structure and function of the cannabinoid receptor CB1

Schierle, Simone, et al.

Pharmakon. 2017 Mar, 5(2): 152-156 (abstract).

Cannabis and cannabinoids - a pharmacological update

Hinz, Burkhard.

Pharmakon. 2017 Mar, 5(2): 109-117 (abstract).

Seventh European Workshop on Cannabinoid Research and IACM Eighth Conference on Cannabinoids in Medicine

Cheer, Joseph F, et al.

Cannabis and Cannabinoid Research. 2016, 1(1): 54-58 (Full).

The use of cannabinoids as anticancer agents

Velasco, Guillermo, et al.

Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2015 Jun 10, 64: 259-266 (Full).

Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System

McPartland, John M, et al.

PLoS One. 2014, 9(3): e89566 (Full online article). 

The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

Pagotto, Uberto, et al.

Endocrine Reviews. 2013 Jul 1, 27(1) (Full).

The endocannabinoid system: an overview

Battista, Natalia, et al.

Frontiers in Behavioral Neuroscience. 2012 Mar 14, (Full online article).

The endocannabinoid system and cancer: therapeutic implication

Guindon, Josee, et al.

British Journal of Pharmacology. 2011 Aug, 163(7): 1447-1463 (Full).

Update on the endocannabinoid system as an anticancer target

Malfitano, Anna Maria, et al.

Expert Opinion on Therapeutic Targets. 2011 Mar, 15(3): 297-308 (abstract).

The endocannabinoid system links gut microbiota to adipogenesis

Muccioli, Giulio G, et al.

Molecular Systems Biology. 2010 Jan 1, 6(1) (Full). 

The Endocannabinoid System and Pain

Guindon, Josee, et al.

CNS Neurological Disorder Drug Targets. 2009 Dec, 8(6): 403-421 (Full).

Endocannabinoid system: An overview of it’s potential in current medical practice.

Mouslech, Z., et al.

Neuro Endocrinology Letters. 2009, 30(2): 153-179 (abstract).

The Endocannabinoid System: An Osteopathic Perspective

McPartland, John M.

The Journal of the American Osteopathic Association. 2008 Oct 1, 108(10): 586-600 (Full).

The Cannabinoid CB2 Receptor as a Target for Inflammation-Dependent Neurodegeneration

Ashton, John C, et al.

Current Neuropharmacology. 2007 Jun, 5(2): 73-80 (Full).

Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity

Bluher, Matthias, et al.

Diabetes. 2006 Nov, 55(11): 3053-3060 (Full).

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Pacher, Pal, et al.

Pharmacological Reviews. 2006 Sep, 58(3): 389-462 (Full).

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus

Monory, Krisztina, et al.

Neuron. 2006 Aug 17, 51(4): 455-466 (Full).

Activation of the Peripheral Endocannabinoid System in Human Obesity

Engeli, Stefan, et al.

Diabetes. 2005 Oct, 54(10): 2838-2843 (Full).

The endocannabinoid system drives neural progenitor proliferation

Aguado, Tania, et al.

The FASEB Journal. 2005 Jul 21, 19(12): 1704-1706 (Full). 

The Endocannabinoid System: Physiology and Pharmacology

Rodriguez de Fonseca, Fernando, et al.

Alcohol & Alcoholism. 2004 Nov 18, 40(1): 2-14 (Full).

The endocannabinoid system: a general view and latest additions

De Petrocellis, Luciano, et al. 

British Journal of Pharmacology. 2004 Mar, 141(5): 765-774 (Full).

The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis

Maccarrone, M, et al.

Cell Death & Differentiation. 2003, 10: 946-955 (Full).

Targeting the endocannabinoid system in cancer therapy: A call for further research

Di Marzo, Vincenzo, et al.

Nature Medicine. 2002 Jun, 8(6): 547-550 (Full).

Metabotropic Glutamate Receptors Drive the Endocannabinoid System in Hippocampus

Varma, Namita, et al.

The Journal of Neuroscience. 2001, 21: 1-5 (Full).

Targeting CB2 receptors and the endocannabinoid system for the treatment of pain

Anand, Praveen, et al.

Brain Research Reviews. 2009 Apr, 60(1): 255-266 (Full). 

Levodopa treatment reverses endocannabinoid system abnormalities in experimental parinsonism

Maccarrone, Maruo, et al.

Journal of Neurochemistry. 2003, 85 (1018-1025) (Full). 

The Endocannabinoid System

Boyd, Steven T.

Pharmacotherapy. 2006 Dec, 26(12): 218-221 (abstract).

Involvement of the endocannabinoid system in drug addiction

Maldonado, Rafael, et al.

Trends in Neurosciences. 2006 Apr, 29(4): 225-232 (abstract).

Endocannabinoid system and stress and anxiety responses

Viveros, M.P., et al.

Pharmacology Biochemistry and Behavior. 2005 Jun, 81(2): 331-342 (abstract).

The endocannabinoid system and it’s therapeutic exploitation

DiMarzo, Vincenzo, et al.

Nature Reviews Drug Discovery. 2004 Sep, 3: 771-784 (abstract).

Exercise activates the endocannabinoid system

Sparling, P.B., et al.

NeuroReport. 2003 Dec 2, 14(17): 2209-2211 (abstract).

The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders

van der Selt, Mario, et al.

European Journal of Pharmacology. 2003 Nov 7, 480 (1-3): 133-150 (abstract).

Endocannabinoids in the immune system and cancer

Parolaro, D, et al.

Prostaglandins, Leukotrienes and Essential Fatty Acids. 2002 Feb, 66(2-3): 319-332 (abstract).

The endocannabinoid system as a target for therapeutic drugs

Piomelli, Daniele, et al. 

Trends in Pharmacological Sciences. 2000 Jun 1, 21(6): 218-224 (abstract).

Endocannabinoid System Research: About Us
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