IMG_8909.JPG

Glioma Tumors & Brain Cancer

US Patent 20160136127 A1, May 19, 2016 - Use of tetrahydrocannabinol and/or cannabidiol for increasing radiosensitivity in the treatment of brain tumour

US Patent 8632825, Jan 21, 2014 - Anti-tumoural effects of cannabinoid combinations

US Patent 6566543, May 20, 2003 - 2-arachidonylglycerl (2-AG) an inhibitor of tumor necrosis factor-alpha and neuroprotector of brain in closed head injury

Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas

Rocha, Francisco Carlos Machado, et al.

Journal of Neuro-Oncology. 2014 Jan, 116(1): 11-24 (abstract).

The intersection between cannabis and cancer in the United States

Bowles, Daniel W, et al.

Critical Reviews in Oncology/Hematology. 2012 Jul, 83(1): 1-10 (abstract).

Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival

Marcu, Jahan P, et al.

Molecular Cancer Therapeutics. 2010 Jan 12, 9: 180-189 (Full).

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

Salazar, Maria, et al.

Journal of Clinical Investigation. 2009 May 1, 119(5): 1359-1372 (Full).

Δ9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells

Galanti, Gil, et al.

Acta Oncologica. 2008, 47: 1062-1070 (Full).

High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells

Widmer, M, et al.

Journal of Neuroscience Research. 2008 Nov 1, 86(14): 3212-3220 (abstract).

Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression

Blazquez, Cristina, et al.

Cancer Research. 2008, 68: 1945-1952 (Full).

Cannabinoids Induce Glioma Stem-like Cell Differentiation and Inhibit Gliomagenesis

Aguado, Tania, et al.

The Journal of Biological Chemistry. 2007 Mar 2, 282(9): 6854-6862 (Full).

Cannabinoids and Gliomas

Velasco, Guillermo, et al.

Molecular Neurobiology. 2007 Apr, 36(1): 60-67 (abstract).

A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme

Guzman, M, et al.

British Journal of Cancer. 2006, 95: 197-203 (Full).

Cannabinoids: potential antitumoral agents?

Guzman, Manuel

Cannabinoids. 2006, 1(2): 15-17 (Full).

The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells

Massi, P, et al.

Cellular and Molecular Life Sciences CMLS. 2006 Sep, 63(17): 2057-2066 (abstract).

Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism

Vaccani, Angelo, et al.

British Journal of Pharmacology. 2005, 144: 1032-1036 (Full).

Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells

McAllister, Sean D, et al.

Journal of Neuro-Oncology. 2005 Aug, 74(1): 31-40 (abstract).

Hypothesis: cannabinoid therapy for the treatment of gliomas?

Velasco, Guillermo, et al.

Neuropharmacology. 2004 Sep, 47(3): 315-323 (abstract).

Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas

Blazquez, Cristina, et al.

Cancer Research. 2004, 64: 5617-5623 (Full).

Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines

Massi, Paola, et al.

The Journal of Pharmacology and Experimental Therapeutics. 2004, 308(3): 838-845 (Full).

Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor

Sanchez, Cristina, et al.

Cancer Research. 2001, 61: 5784-5789 (Full).

Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors

Jacobsson, Stig, et al.

The Journal of Pharmacology and Experimental Therapeutics. 2001 Dec, 299(3): 951-959 (Full).

Δ9-Tetrahydrocannabinol induces apoptosis in C6 glioma cells

Sanchez, Cristina, et al.

FEBS Letters. 1998, 436: 6-10 (Full).

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells

Mackie, Ken, et al.

Proceedings of the National Academy of Science. 1992 May, 89: 3825-3829 (Full).