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Insomnia

Statistics on Insomnia:

50-70 million US adults have a sleep disorder. Insomnia is the most common specific sleep disorder, with short term issues reported by about 30% of adults and chronic insomnia by 10%.

37% of 20-39 year-olds report short sleep duration.

40% of 40-59 year-olds report short sleep duration.

Drowsy driving is responsible for 1,550 fatalities and 40,000 nonfatal injuries annually in the United States.

100,000 deaths occur each year in US hospitals due to medical errors and sleep deprivation has been shown to make a significant contribution. 
(Source: American Sleep Association, www.sleepassociation.org/sleep/sleep-statistics/

US Patent 20150342922 A1, Dec 3, 2015 - Cannabinoid formulation for the sedation of a human or animal

US Patent 8207230, Jun 26, 2012 - Functional role for cannabinoids in autonomic stability during sleep

Cannabis and Insomnia

Tringale, Rolando, et al.

O’Shaughnessy’s. 2011 Apr, 31-32.

Anandamide Enhances Extracellular Levels of Adenosine and Induces Sleep: An In Vivo Microdialysis Study 

Murillo-Rodriguez, Eric, et al.

Sleep. 2003 Aug, 26(8): 943-947.

Pharmacology of Cannabinoids

Grotenhermen, Franjo.

Neuroendocrinology Letters. 2004 Apr, 1-2: 15-23.

Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex, a Cannabis-Based Medicine 

Russo, Ethan B., et al.

Chemistry & Biodiversity. 2007 Aug 21, 4(8): 1729-1743 (abstract).

Cannabidiol, a constituent of Cannabis Sativa, modulates sleep in rats 

Murillo-Rodriguez, Eric, et al.

FEBS Letters. 2006 Aug 7, 581(18): 4337-4345.

The modulatory role of endocannabinoids and sleep

Murillo-Rodriguez, Eric.

Revisita de Neurologia. 2008, 46(3): 160-166 (abstract).  

The role of the CB1 receptor in the regulation of sleep

Murillo-Rodriguez, Eric.

Progress in Neuro-Psycopharmacology and Biological Psychiatry. 2008 Aug 1, 32(6): 1420-1427 (abstract).

Effects of Δ-9 Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults

Nicholson, Anthony N., et al.

Journal of Clinical Psychopharmacology. 2004 Jun, 24(3): 305-313 (abstract).

Established and potential therapeutic applications of cannabinoids in oncology

Walsh, Declan, et al.

Supportive Care in Cancer. 2003 Mar, 11(3): 137-143 (abstract).

Functional role for cannabinoids in respiratory stability during sleep.

Carley, DW, et al.

Sleep. 2002, 25(4): 391-398 (abstract).